… ), perhaps due to their metabolism in RT4 cells. Therefore, … CYP2A13 expressed in the
bladder efficiently bioactivates 4-ABP to form DNA adducts. These data are consistent with human …

… , the bulk of this review focuses on NAT-mediated metabolism. NATs serve as a line of defense
by … For instance, dogs lack NAT expression in either liver or bladder, yet are still prone to …

… for bladder cancer [17,44], the appropriate inhibition … CYP2A13 might stop the metabolism
of some aromatic amines from smoke (eg, 4-aminobiphenyl) that is metabolized by CYP2A13 …

… such as 4-aminobiphenyl (ABP) and 2-aminofluorene (AF) require metabolic activation to
form … For example, a recent report showed that CYP2A13 expressed in the urinary bladder …

… undergoes metabolic activation to N-hydroxy-4-aminobiphenyl … found in TP53 in human
bladder tumors the present study used … Data are expressed as the percentage of absorbance per …

… activated by the metabolic enzyme CYP2A13, are potent procarcinogens. Smoking plays a
role in carcinogenesis in the human bladder, which expresses CYP2A13 … Given that the risk …

… in human urine, the results of which are generally expressed … seriously pursue analysis of
human urine for NNN itself until … other carcinogens such as 4-aminobiphenyl, even though the …

… of NNK metabolites in the human urine has been linked to … of expressed CYP2A13 in human
lungs and the rates of NNK … : Novel mechanistic insights using 4aminobiphenyl as a model …

… DNA adducts of 4-aminobiphenyl (4-ABP), a bladder carcinogen … Scheme of the metabolic
activation of 4-ABP leading to DNA … oxidation by P450 expressed in the bladder epithelium to …

… that the presence of CYP2A13*2 was associated with a reduced risk for bladder cancer, …
In conclusion, wild-type and 8 CYP2A13 variants were expressed in 293FT cells and their …